ALDOSTERONE SECRETION AND PRIMARY AND MALIGNANT HYPERTENSION *
نویسندگان
چکیده
منابع مشابه
Aldosterone secretion and primary and malignant hypertension.
After the synthesis of desoxycorticosterone (DOC), it became apparent that this corticosteroid, the physiological effects of which are concerned primarily with sodium and potassium metabolism, can produce a state of hypertension both in animals and in man (1, 2). The induced hypertension is dependent upon the administration of adequate amounts of dietary sodium, whereas the hypertensive state, ...
متن کاملMalignant hypertension: effect of therapy on renin and aldosterone.
Plasma renin activity (PRA) and aldosterone secretion rate (ASR) were measured in 22 patients in balance on a 100 mEq sodium diet during the malignant phase of hypertension and at intervals during long-term follow-up on pharmacological therapy. Three patients had normal PRA and ASR during malignant hypertension. Eighty-six per cent of patients had an increased ASR, but only in 36% was PRA conco...
متن کاملThe renin-angiotensin-aldosterone system in primary and secondary hypertension.
Important advances have been made in understanding the role of the renin-angiotensin-aldosterone system in the pathogenesis and diagnosis of hypertensive disorders. Measurement of plasma renin activity (PRA) and aldosterone is very important in the assessment of secondary hypertension. Hypertensions with increased PRA include renovascular hypertension, some cases of unilateral and bilateral ren...
متن کاملEssential hypertension and aldosterone.
MANY FACTORS have been implicated in the etiology of essential hypertension and at present the primary cause of this disease remains obscure. The relationship of sodium to the development of hypertension and the question of involvement of the adrenal cortex has been the subject of numerous investigations. Efforts by earlier investigators to show a hypersecretion of corticosteroids in this condi...
متن کاملUrinary aldosterone and hypertension.
A POSSIBLE ETIOLOGIC ROLE of the 18.1kadrenal cortex in the genesis of clinical hypertension has been recognized since Goldblatt's demonstration in 1937 that adrenalectomy prevents the expected development of hypertension following bilateral renal artery constriction.' Recently, interest in this possibility has been intensified by reports that some hypertensive patients excrete2-6 and secrete7 ...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1960
ISSN: 0021-9738
DOI: 10.1172/jci104124